Crystal structure of FASL and DcR3 complex

Summary for 4MSV

Related4EN0 3MHD 4J6G 4KGG 4KGQ 3K51
DescriptorTumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor ligand superfamily member 6, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsfasl, dcr3, tnf, tnfr, tnf6, structural genomics, psi-biology, new york structural genomics, research consortium, nysgrc, immunity, tnf supe cd95l, fas ligand, membrane, atoms-to-animals: the immune function network, ifn, jelly-roll fold, bind tnf receptor fas, protein structure initiative, new york structural genomics research consortium, cd95l, tnf superfamily, secreted protein, cytokine, immune system
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted . FasL intracellular domain: Nucleus O95407
Secreted P48023
Total number of polymer chains2
Total molecular weight36505.57
Primary citation
Liu, W.,Ramagopal, U.,Cheng, H.,Bonanno, J.B.,Toro, R.,Bhosle, R.,Zhan, C.,Almo, S.C.
Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24:2016-2023, 2016
PubMed: 27806260 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2016.09.009
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.223305.0%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution