4MSV

Crystal structure of FASL and DcR3 complex

?

Functional Information from GO Data

ChainGOidnamespacecontents
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0038023molecular_functionsignaling receptor activity
B0006915biological_processapoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0033209biological_processtumor necrosis factor-mediated signaling pathway
A0005901cellular_componentcaveola
A0060205cellular_componentcytoplasmic vesicle lumen
A0009897cellular_componentexternal side of plasma membrane
A0070062cellular_componentextracellular exosome
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005887cellular_componentintegral component of plasma membrane
A0043202cellular_componentlysosomal lumen
A0005634cellular_componentnucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0005886cellular_componentplasma membrane
A0005125molecular_functioncytokine activity
A0005123molecular_functiondeath receptor binding
A0005102molecular_functionsignaling receptor binding
A0005164molecular_functiontumor necrosis factor receptor binding
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0006915biological_processapoptotic process
A0097190biological_processapoptotic signaling pathway
A0007267biological_processcell-cell signaling
A0030644biological_processcellular chloride ion homeostasis
A0019221biological_processcytokine-mediated signaling pathway
A0048388biological_processendosomal lumen acidification
A0097191biological_processextrinsic apoptotic signaling pathway
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0006955biological_processimmune response
A0006925biological_processinflammatory cell apoptotic process
A0070266biological_processnecroptotic process
A0097527biological_processnecroptotic signaling pathway
A0016525biological_processnegative regulation of angiogenesis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0043065biological_processpositive regulation of apoptotic process
A0008284biological_processpositive regulation of cell proliferation
A2000353biological_processpositive regulation of endothelial cell apoptotic process
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0043123biological_processpositive regulation of I-kappaB kinase/NF-kappaB signaling
A0043525biological_processpositive regulation of neuron apoptotic process
A1902041biological_processregulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903514biological_processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
A0070848biological_processresponse to growth factor
A0032496biological_processresponse to lipopolysaccharide
A0046666biological_processretinal cell programmed cell death
A0007165biological_processsignal transduction
A0070231biological_processT cell apoptotic process
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE MG B 301
ChainResidue
BCYS132
BPRO133
BALA136
BSER159
BSER161
BHOH424

AC26BINDING SITE FOR RESIDUE GOL A 301
ChainResidue
AASN215
ATYR218
AGLN220
ALEU222
BLEU85
BARG89

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GOL_4msv_A_30110GLYCEROL binding site
ChainResidueligand
BLEU85GOL: GLYCEROL
BARG89GOL: GLYCEROL
AMET213-ASN215GOL: GLYCEROL
ATYR218-LEU222GOL: GLYCEROL

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Cleavage; by ADAM10. {ECO:0000305}.
ChainResidueDetails
ANA*

SWS_FT_FI22Cleavage; by SPPL2A. {ECO:0000305}.
ChainResidueDetails
ANA*

SWS_FT_FI322Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
ChainResidueDetails
ANA*

?

Catalytic Information from CSA

site_idNumber of ResiduesDetails