X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 12 nucleobase

Summary for 4LZ1
Related3QLP 4DIH 4DII 4LZ4
Related PRD IDPRD_000020
DescriptorThrombin light chain, Thrombin heavy chain, Thrombin Binding Aptamer, ... (8 entities in total)
Functional Keywordsprotein-dna complex, blood coagulation, aptamer, inhibitor-dna complex, dna aptamer, g-quadruplex, serine protease, hydrolase, abasic furan, dna thymine nucleobase deletion, blood, hydrolase-dna complex, hydrolase-hydrolase inhibitor-dna complex, hydrolase/hydrolase inhibitor/dna
Biological sourceHomo sapiens (human)
Total number of polymer chains3
Total formula weight39232.99
Pica, A.,Russo Krauss, I.,Merlino, A.,Sica, F. (deposition date: 2013-07-31, release date: 2014-01-08, Last modification date: 2020-07-29)
Primary citationMerlino, A.,Nagatoishi, S.,Pica, A.,Russo Krauss, I.,Sica, F.,Sugimoto, N.
Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.
Febs J., 280:6581-6588, 2013
PubMed: 24128303
DOI: 110.1111/febs.12561
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23