4LB2

X-ray study of human serum albumin complexed with idarubicin

Summary for 4LB2

Entry DOI	10.2210/pdb4lb2/pdb
Related	4L8U 4L9K 4L9Q 4LA0 4LB9
Descriptor	SERUM ALBUMIN, IDARUBICIN (3 entities in total)
Functional Keywords	plasma protein, cancer, oncology drug complex, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02768
Total number of polymer chains	2
Total formula weight	135132.41
Authors	Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (deposition date: 2013-06-20, release date: 2013-07-24, Last modification date: 2014-02-19)
Primary citation	Wang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C. Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim.Biophys.Acta, 1830:5356-5374, 2013 Cited by PubMed Abstract: Serum albumin is a major pharmacokinetic effector of drugs. To gain further insight into albumin binding chemistry, the crystal structures of six oncology agents were determined in complex with human serum albumin at resolutions of 2.8 to 2.0Å: camptothecin, 9-amino-camptothecin, etoposide, teniposide, bicalutamide and idarubicin. PubMed: 23838380 DOI: 10.1016/j.bbagen.2013.06.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation