4LB9
X-ray study of human serum albumin complexed with etoposide
Summary for 4LB9
Entry DOI | 10.2210/pdb4lb9/pdb |
Related | 4L8U 4L9K 4L9Q 4LA0 4LB2 |
Descriptor | SERUM ALBUMIN, MYRISTIC ACID, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | plasma protein, cancer, oncology drug complex, transport protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02768 |
Total number of polymer chains | 1 |
Total formula weight | 68073.26 |
Authors | Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (deposition date: 2013-06-20, release date: 2013-07-24, Last modification date: 2024-11-06) |
Primary citation | Wang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C. Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim.Biophys.Acta, 1830:5356-5374, 2013 Cited by PubMed Abstract: Serum albumin is a major pharmacokinetic effector of drugs. To gain further insight into albumin binding chemistry, the crystal structures of six oncology agents were determined in complex with human serum albumin at resolutions of 2.8 to 2.0Å: camptothecin, 9-amino-camptothecin, etoposide, teniposide, bicalutamide and idarubicin. PubMed: 23838380DOI: 10.1016/j.bbagen.2013.06.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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