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4LB9

X-ray study of human serum albumin complexed with etoposide

Summary for 4LB9
Entry DOI10.2210/pdb4lb9/pdb
Related4L8U 4L9K 4L9Q 4LA0 4LB2
DescriptorSERUM ALBUMIN, MYRISTIC ACID, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywordsplasma protein, cancer, oncology drug complex, transport protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02768
Total number of polymer chains1
Total formula weight68073.26
Authors
Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (deposition date: 2013-06-20, release date: 2013-07-24, Last modification date: 2024-11-06)
Primary citationWang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C.
Structural studies of several clinically important oncology drugs in complex with human serum albumin.
Biochim.Biophys.Acta, 1830:5356-5374, 2013
Cited by
PubMed Abstract: Serum albumin is a major pharmacokinetic effector of drugs. To gain further insight into albumin binding chemistry, the crystal structures of six oncology agents were determined in complex with human serum albumin at resolutions of 2.8 to 2.0Å: camptothecin, 9-amino-camptothecin, etoposide, teniposide, bicalutamide and idarubicin.
PubMed: 23838380
DOI: 10.1016/j.bbagen.2013.06.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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