4L8U

X-ray study of human serum albumin complexed with 9 amino camptothecin

Summary for 4L8U

Entry DOI	10.2210/pdb4l8u/pdb
Related	4L9K 4L9Q 4LA0 4LB2 4LB9
Descriptor	Serum albumin, MYRISTIC ACID, (2S)-2-[1-amino-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoic acid, ... (4 entities in total)
Functional Keywords	plasma protein, oncology drugs, protein drug complex, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02768
Total number of polymer chains	1
Total formula weight	68094.46
Authors	Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (deposition date: 2013-06-17, release date: 2013-07-24, Last modification date: 2017-11-15)
Primary citation	Wang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C. Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim.Biophys.Acta, 1830:5356-5374, 2013 Cited by PubMed: 23838380 DOI: 10.1016/j.bbagen.2013.06.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation