4L8U

X-ray study of human serum albumin complexed with 9 amino camptothecin

Summary for 4L8U

Related4L9K 4L9Q 4LA0 4LB2 4LB9
DescriptorSerum albumin, MYRISTIC ACID, (2S)-2-[1-amino-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoic acid, ... (4 entities in total)
Functional Keywordsplasma protein, oncology drugs, protein drug complex, transport protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02768
Total number of polymer chains1
Total molecular weight68094.46
Authors
Wang, Z.,Ho, J.X.,Ruble, J.,Rose, J.P.,Carter, D.C. (deposition date: 2013-06-17, release date: 2013-07-24, Last modification date: 2017-11-15)
Primary citation
Wang, Z.M.,Ho, J.X.,Ruble, J.R.,Rose, J.,Ruker, F.,Ellenburg, M.,Murphy, R.,Click, J.,Soistman, E.,Wilkerson, L.,Carter, D.C.
Structural studies of several clinically important oncology drugs in complex with human serum albumin.
Biochim.Biophys.Acta, 1830:5356-5374, 2013
PubMed: 23838380 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbagen.2013.06.032
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.01 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243100.3%4.5%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution