4KQV

Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor

Summary for 4KQV

• Entry DOI: 10.2210/pdb4kqv/pdb
• Related: 4HY1 4K4O 4KFG 4KSG 4KSH 4KTN
• Descriptor: Topoisomerase IV, subunit B, IODIDE ION, 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, ... (4 entities in total)
• Functional Keywords: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna, isomerase
• Biological source: Francisella tularensis subsp. holarctica
• Total number of polymer chains: 2
• Total formula weight: 89785.70

Authors

Bensen, D.C.,Akers-Rodriguez, S.,Lam, T.,Tari, L.W. (deposition date: 2013-05-15, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (2.38 Å)