4KQV
Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Topoisomerase IV, subunit B | polymer | 390 | 43950.8 | 2 | UniProt (Q2A1P5) Pfam (PF02518) Pfam (PF00204) UniProt (by SIFTS) (A0A0J9WZF0) | Francisella tularensis subsp. holarctica | |
| 2 | C, D, F, G, H... (A, B) | IODIDE ION | non-polymer | 126.9 | 8 | Chemie (IOD) | |||
| 3 | E, L (A, B) | 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine | non-polymer | 434.5 | 2 | Chemie (DOO) | |||
| 4 | M, N (A, B) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 382 (UniProt: Q2A1P5)
| PDB | External Database | Details |
|---|---|---|
| Pro 258 | Leu 258 | variant |
| Leu 383 | - | expression tag |
| Glu 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
| His 390 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87901.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1884.2 | |
| All* | Total formula weight | 89785.7 |
