4KQV

Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Topoisomerase IV, subunit B	polymer	390	43950.8	2	UniProt (Q2A1P5) Pfam (PF02518) Pfam (PF00204) UniProt (by SIFTS) (A0A0J9WZF0) In PDB	Francisella tularensis subsp. holarctica
2	A, B	IODIDE ION	non-polymer		126.9	8	Chemie (IOD)
3	A, B	6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine	non-polymer		434.5	2	Chemie (DOO)
4		water	water		18.0	129	Chemie (HOH)

Sequence modifications

A, B: 1 - 382 (UniProt: Q2A1P5)

PDB	External Database	Details
Pro 258	Leu 258	variant
Leu 383	-	expression tag
Glu 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87901.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1884.2
All*	Total formula weight	89785.7

*Water molecules are not included.