4KQV

Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor

4KQV の概要

• エントリーDOI: 10.2210/pdb4kqv/pdb
• 関連するPDBエントリー: 4HY1 4K4O 4KFG 4KSG 4KSH 4KTN
• 分子名称: Topoisomerase IV, subunit B, IODIDE ION, 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, ... (4 entities in total)
• 機能のキーワード: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna, isomerase
• 由来する生物種: Francisella tularensis subsp. holarctica
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89785.70

構造登録者

Bensen, D.C.,Akers-Rodriguez, S.,Lam, T.,Tari, L.W. (登録日: 2013-05-15, 公開日: 2014-01-15, 最終更新日: 2023-09-20)

• 主引用文献: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

実験手法

X-RAY DIFFRACTION (2.38 Å)