4KOE
Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae
Summary for 4KOE
Entry DOI | 10.2210/pdb4koe/pdb |
Related | 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE 3RAF 4KPE 4KPF |
Descriptor | DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, E-site DNA1, ... (8 entities in total) |
Functional Keywords | protein-dna cleavage complex, isomerase-dna-inhibitor complex, topoisomerase iia, quinolone, trovafloxacin, isomerase/dna/inhibitor |
Biological source | Streptococcus pneumoniae More |
Cellular location | Cell membrane ; Peripheral membrane protein : P72525 |
Total number of polymer chains | 8 |
Total formula weight | 185662.08 |
Authors | Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2013-05-11, release date: 2014-11-26, Last modification date: 2017-11-15) |
Primary citation | Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,Fisher, L.M.,Sanderson, M.R. Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions To be Published, |
Experimental method | X-RAY DIFFRACTION (3.02 Å) |
Structure validation
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