4KOE

Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae

Summary for 4KOE

• Entry DOI: 10.2210/pdb4koe/pdb
• Related: 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE 3RAF 4KPE 4KPF
• Descriptor: DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, E-site DNA1, ... (8 entities in total)
• Functional Keywords: protein-dna cleavage complex, isomerase-dna-inhibitor complex, topoisomerase iia, quinolone, trovafloxacin, isomerase/dna/inhibitor
• Biological source: Streptococcus pneumoniae; More
• Cellular location: Cell membrane ; Peripheral membrane protein : P72525
• Total number of polymer chains: 8
• Total formula weight: 185662.08

Authors

Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2013-05-11, release date: 2014-11-26, Last modification date: 2017-11-15)

• Primary citation: Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,Fisher, L.M.,Sanderson, M.R.; Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions; To be Published,

Experimental method

X-RAY DIFFRACTION (3.02 Å)