4KPE
Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate
Summary for 4KPE
Entry DOI | 10.2210/pdb4kpe/pdb |
Related | 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE 3RAF 4KOE 4KPF |
Descriptor | DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, E-site DNA1, ... (9 entities in total) |
Functional Keywords | protein-dna cleavage complex, isomerase-dna-inhibitor complex, topoisomerase iia, quinolone, achn-245, isomerase/dna/inhibitor |
Biological source | Streptococcus pneumoniae More |
Total number of polymer chains | 8 |
Total formula weight | 185568.15 |
Authors | Laponogov, I.,Pan, X.-S.,Vesekov, D.A.,Cirz, R.T.,Wagman, A.S.,Moser, H.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2013-05-13, release date: 2014-11-26, Last modification date: 2024-10-16) |
Primary citation | Laponogov, I.,Pan, X.S.,Veselkov, D.A.,Cirz, R.T.,Wagman, A.,Moser, H.E.,Fisher, L.M.,Sanderson, M.R. Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones. Open Biol, 6:-, 2016 Cited by PubMed: 27655731DOI: 10.1098/rsob.160157 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.43 Å) |
Structure validation
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