4KPE

Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate

Summary for 4KPE

Entry DOI	10.2210/pdb4kpe/pdb
Related	2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE 3RAF 4KOE 4KPF
Descriptor	DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, E-site DNA1, ... (9 entities in total)
Functional Keywords	protein-dna cleavage complex, isomerase-dna-inhibitor complex, topoisomerase iia, quinolone, achn-245, isomerase/dna/inhibitor
Biological source	Streptococcus pneumoniae More
Total number of polymer chains	8
Total formula weight	185568.15
Authors	Laponogov, I.,Pan, X.-S.,Vesekov, D.A.,Cirz, R.T.,Wagman, A.S.,Moser, H.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2013-05-13, release date: 2014-11-26, Last modification date: 2020-01-29)
Primary citation	Laponogov, I.,Pan, X.S.,Veselkov, D.A.,Cirz, R.T.,Wagman, A.,Moser, H.E.,Fisher, L.M.,Sanderson, M.R. Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones. Open Biol, 6:-, 2016 Cited by PubMed: 27655731 DOI: 10.1098/rsob.160157 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.43 Å)

Structure validation