4KOE
Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA topoisomerase 4 subunit A | polymer | 496 | 56455.4 | 2 | UniProt (P72525) Pfam (PF00521) In PDB | Streptococcus pneumoniae | Topoisomerase IV subunit A |
2 | C, D | DNA topoisomerase 4 subunit B | polymer | 268 | 30415.7 | 2 | UniProt (Q59961) Pfam (PF01751) Pfam (PF00986) In PDB | Streptococcus pneumoniae serotype 4 | |
3 | E | E-site DNA1 | polymer | 7 | 2121.4 | 1 | |||
4 | F | E-site DNA2 | polymer | 11 | 3348.2 | 1 | |||
5 | G | E-site DNA3 | polymer | 7 | 2113.4 | 1 | |||
6 | H | E-site DNA4 | polymer | 11 | 3358.2 | 1 | |||
7 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
8 | F, H | Trovafloxacin | non-polymer | 416.4 | 2 | Chemie (TR6) |
Sequence modifications
A, B: 1 - 488 (UniProt: P72525)
C, D: 404 - 647 (UniProt: Q59961)
PDB | External Database | Details |
---|---|---|
Thr 257 | Ile 257 | ENGINEERED MUTATION |
Leu 489 | - | EXPRESSION TAG |
Glu 490 | - | EXPRESSION TAG |
His 491 | - | EXPRESSION TAG |
His 492 | - | EXPRESSION TAG |
His 493 | - | EXPRESSION TAG |
His 494 | - | EXPRESSION TAG |
His 495 | - | EXPRESSION TAG |
His 496 | - | EXPRESSION TAG |
PDB | External Database | Details |
---|---|---|
Met 380 | - | EXPRESSION TAG |
Gly 381 | - | EXPRESSION TAG |
His 382 | - | EXPRESSION TAG |
His 383 | - | EXPRESSION TAG |
His 384 | - | EXPRESSION TAG |
His 385 | - | EXPRESSION TAG |
His 386 | - | EXPRESSION TAG |
His 387 | - | EXPRESSION TAG |
His 388 | - | EXPRESSION TAG |
His 389 | - | EXPRESSION TAG |
His 390 | - | EXPRESSION TAG |
His 391 | - | EXPRESSION TAG |
Ser 392 | - | EXPRESSION TAG |
Ser 393 | - | EXPRESSION TAG |
Gly 394 | - | EXPRESSION TAG |
His 395 | - | EXPRESSION TAG |
Ile 396 | - | EXPRESSION TAG |
Asp 397 | - | EXPRESSION TAG |
Asp 398 | - | EXPRESSION TAG |
Asp 399 | - | EXPRESSION TAG |
Asp 400 | - | EXPRESSION TAG |
Lys 401 | - | EXPRESSION TAG |
His 402 | - | EXPRESSION TAG |
Met 403 | - | EXPRESSION TAG |
Ile 460 | Val 460 | ENGINEERED MUTATION |
Ala 644 | Thr 644 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 184683.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 978.5 | |
All* | Total formula weight | 185662.1 |