4JHT
Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1)
Summary for 4JHT
Entry DOI | 10.2210/pdb4jht/pdb |
Related | 2FDB 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3H8O 3H8R 3H8X 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T3Y 3T4H 3T4V |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase AlkB, 8-hydroxyquinoline-5-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | double-stranded beta helix, jelly-roll motif, oxidoreductase, dioxygenase, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 23326.52 |
Authors | Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-03-05, release date: 2013-06-26, Last modification date: 2023-11-08) |
Primary citation | Hopkinson, R.J.,Tumber, A.,Yapp, C.,Chowdhury, R.,Aik, W.,Che, K.H.,Li, X.S.,Kristensen, J.B.L.,King, O.N.F.,Chan, M.C.,Yeoh, K.K.,Choi, H.,Walport, L.J.,Thinnes, C.C.,Bush, J.T.,Lejeune, C.,Rydzik, A.M.,Rose, N.R.,Bagg, E.A.,McDonough, M.A.,Krojer, T.,Yue, W.W.,Ng, S.S.,Olsen, L.,Brennan, P.E.,Oppermann, U.,Muller-Knapp, S.,Klose, R.J.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chem Sci, 4:3110-3117, 2013 Cited by PubMed: 26682036DOI: 10.1039/C3SC51122G PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
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