4H1N

Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel

4H1N の概要

• エントリーDOI: 10.2210/pdb4h1n/pdb
• 関連するPDBエントリー: 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (6 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57025.51

構造登録者

Shah, M.B.,Jang, H.H.,Stout, C.D.,Halpert, J.R. (登録日: 2012-09-10, 公開日: 2013-01-16, 最終更新日: 2023-09-13)

• 主引用文献: Shah, M.B.,Jang, H.H.,Zhang, Q.,David Stout, C.,Halpert, J.R.; X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket.; Arch.Biochem.Biophys., 530:64-72, 2013; PubMed: 23296089; DOI: 10.1016/j.abb.2012.12.016

実験手法

X-RAY DIFFRACTION (2.99 Å)