4H1N
Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytochrome P450 2B4 | polymer | 479 | 54507.4 | 1 | UniProt (P00178) Pfam (PF00067) In PDB | Oryctolagus cuniculus (European rabbit Japanese white rabbit domestic rabbit rabbits) | CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1 |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE | non-polymer | 494.6 | 3 | Chemie (CM5) | |||
4 | A | Clopidogrel | non-polymer | 321.8 | 1 | Chemie (CGE) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 20 - 491 (UniProt: P00178)
PDB | External Database | Details |
---|---|---|
Ala 21 | Glu 2 | engineered mutation |
- | Phe 3 | deletion |
- | Ser 4 | deletion |
- | Leu 5 | deletion |
- | Leu 6 | deletion |
- | Leu 7 | deletion |
- | Leu 8 | deletion |
- | Leu 9 | deletion |
- | Ala 10 | deletion |
- | Phe 11 | deletion |
- | Leu 12 | deletion |
- | Ala 13 | deletion |
- | Gly 14 | deletion |
- | Leu 15 | deletion |
- | Leu 16 | deletion |
- | Leu 17 | deletion |
- | Leu 18 | deletion |
- | Leu 19 | deletion |
- | Phe 20 | deletion |
- | Arg 21 | deletion |
Lys 22 | Gly 22 | engineered mutation |
Lys 23 | His 23 | engineered mutation |
Thr 24 | Pro 24 | engineered mutation |
Ser 25 | Lys 25 | engineered mutation |
Ser 26 | Ala 26 | engineered mutation |
Lys 27 | His 27 | engineered mutation |
Lys 29 | Arg 29 | engineered mutation |
Ser 221 | Pro 221 | SEE REMARK 999 |
Tyr 226 | His 226 | engineered mutation |
Ala 297 | Phe 297 | engineered mutation |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54507.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2518.1 | |
All* | Total formula weight | 57025.5 |