4H1N
Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008392 | molecular_function | arachidonate epoxygenase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| A | 0019373 | biological_process | epoxygenase P450 pathway |
| A | 0020037 | molecular_function | heme binding |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM A 501 |
| Chain | Residue |
| A | ARG98 |
| A | VAL367 |
| A | HIS369 |
| A | LEU392 |
| A | PRO428 |
| A | PHE429 |
| A | SER430 |
| A | ARG434 |
| A | CYS436 |
| A | GLY438 |
| A | ALA442 |
| A | ILE114 |
| A | CGE505 |
| A | TRP121 |
| A | ARG125 |
| A | ILE179 |
| A | ALA298 |
| A | GLY299 |
| A | THR303 |
| A | ILE363 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CM5 A 502 |
| Chain | Residue |
| A | GLU250 |
| A | GLU322 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CM5 A 503 |
| Chain | Residue |
| A | LEU43 |
| A | MET46 |
| A | ASP47 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CM5 A 504 |
| Chain | Residue |
| A | LYS186 |
| A | PHE188 |
| A | PHE195 |
| A | LEU198 |
| A | PHE244 |
| A | PHE296 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CGE A 505 |
| Chain | Residue |
| A | ILE101 |
| A | ILE114 |
| A | ILE209 |
| A | ALA297 |
| A | ALA298 |
| A | VAL367 |
| A | VAL477 |
| A | HEM501 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | THR404 |
| A | PRO405 |
| A | ASN406 |
| A | THR407 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGKRICLG |
| Chain | Residue | Details |
| A | PHE429-GLY438 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | GLN455 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P00176 |
| Chain | Residue | Details |
| A | GLN147 |
