4H1N
Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel
Summary for 4H1N
Entry DOI | 10.2210/pdb4h1n/pdb |
Related | 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (6 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 1 |
Total formula weight | 57025.51 |
Authors | Shah, M.B.,Jang, H.H.,Stout, C.D.,Halpert, J.R. (deposition date: 2012-09-10, release date: 2013-01-16, Last modification date: 2023-09-13) |
Primary citation | Shah, M.B.,Jang, H.H.,Zhang, Q.,David Stout, C.,Halpert, J.R. X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket. Arch.Biochem.Biophys., 530:64-72, 2013 Cited by PubMed: 23296089DOI: 10.1016/j.abb.2012.12.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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