4GUA

Alphavirus P23pro-zbd

Summary for 4GUA

• Entry DOI: 10.2210/pdb4gua/pdb
• Related: 2HWK 3GPG 3GPO 3GPQ 3GQO 3TRK
• Descriptor: Non-structural polyprotein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: viral precursor polyprotein, protease, zinc-binding, hydrolase
• Biological source: Sindbis virus (SINV)
• Cellular location: Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. P123': Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. Non-structural protein 3': Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side: P03317
• Total number of polymer chains: 3
• Total formula weight: 229719.78

Authors

Shin, G.,Yost, S.,Miller, M.,Marcotrigiano, J. (deposition date: 2012-08-29, release date: 2012-10-03, Last modification date: 2023-09-13)

• Primary citation: Shin, G.,Yost, S.A.,Miller, M.T.,Elrod, E.J.,Grakoui, A.,Marcotrigiano, J.; Structural and functional insights into alphavirus polyprotein processing and pathogenesis.; Proc.Natl.Acad.Sci.USA, 109:16534-16539, 2012; PubMed: 23010928; DOI: 10.1073/pnas.1210418109

Experimental method

X-RAY DIFFRACTION (2.854 Å)