3GQO

Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose

Summary for 3GQO

Related3GPG 3GPO 3GPQ 3GQE
DescriptorNon-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
Functional Keywordsmacro domain, x domain, venezuelan equine encephalitis virus, alphavirus, virus, adp-ribose, vizier, viral enzymes involved in replication, viral protein
Biological sourceVenezuelan equine encephalitis virus
Cellular locationNon-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side  P36328
Total number of polymer chains4
Total molecular weight75696.75
Authors
Malet, H.,Jamal, S.,Coutard, B.,Ferron, F.,Canard, B. (deposition date: 2009-03-24, release date: 2009-07-21, Last modification date: 2017-09-20)
Primary citation
Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83:6534-6545, 2009
PubMed: 19386706 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.00189-09
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26280.2%6.8%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3gqo
no rotation
Molmil generated image of 3gqo
rotated about x axis by 90°
Molmil generated image of 3gqo
rotated about y axis by 90°