Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GUA

Alphavirus P23pro-zbd

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1701

Chain	Residue
A	GLN1081
A	THR1105
A	ARG1106
A	LYS1107
A	ARG1535
A	GLY1551

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1702

Chain	Residue
A	HIS1098
C	LYS1130
A	THR1018
A	CYS1021
A	LYS1024

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1703

Chain	Residue
A	THR1074
A	ASN1154
A	LYS1559
A	SER1602

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1704

Chain	Residue
A	PRO1172
A	VAL1173
A	LYS1192
A	GLU1194

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1705

Chain	Residue
A	THR1399
A	HIS1423

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1706

Chain	Residue
A	ARG1535
A	THR1552
A	LYS1553

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1707

Chain	Residue
A	SER1539
A	THR1540

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1708

Chain	Residue
A	ARG1620
A	LEU1624

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1709

Chain	Residue
A	SER1056
A	LYS1254
A	MES1717

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1710

Chain	Residue
A	TYR1110
A	PHE1125
A	GLY1129
A	LYS1130

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1711

Chain	Residue
A	THR1038
A	GLY1039
A	CYS1040

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1712

Chain	Residue
A	GLY1235

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1713

Chain	Residue
A	ASP1091
A	SER1092
C	LYS1080

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1714

Chain	Residue
A	ASN1178
A	PHE1180
A	LYS1181
A	HIS1182
A	ARG1197
A	LYS1198

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1715

Chain	Residue
A	LYS1553
A	HIS1622

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES A 1716

Chain	Residue
A	ALA1369
A	ASN1371
A	GLU1378
A	SER1457
A	THR1458
A	GLY1459
A	ILE1460
A	TYR1461

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES A 1717

Chain	Residue
A	HIS1055
A	SER1056
A	LYS1254
A	THR1255
A	ARG1258
A	GLU1518
A	SO41709

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES A 1718

Chain	Residue
A	HIS1527
A	ASP1529
A	MET1613
A	ALA1615
A	THR1617
A	GLU1619

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1719

Chain	Residue
A	CYS1610
A	CYS1612
A	CYS1635
A	CYS1653

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1701

Chain	Residue
B	LYS1533
B	SER1539
B	THR1540

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1702

Chain	Residue
B	ARG1226
B	ASN1262
C	PRO1266
C	THR1510

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1703

Chain	Residue
B	THR1399
B	HIS1423

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1704

Chain	Residue
B	TYR1614
B	ARG1620
B	LEU1624

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1705

Chain	Residue
B	ASN1178
B	ARG1197
B	LYS1198

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES B 1706

Chain	Residue
B	HIS1055
B	SER1056
B	THR1255
B	ARG1258
B	GLU1518

site_id	CC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES B 1707

Chain	Residue
B	SER1457
B	THR1458
B	GLY1459
B	ILE1460
B	TYR1461
B	ALA1369
B	ALA1370
B	ASN1371
B	GLU1378

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1708

Chain	Residue
B	CYS1610
B	CYS1612
B	CYS1635
B	CYS1653

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1701

Chain	Residue
C	SER1539
C	THR1540

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1702

Chain	Residue
C	SER1056
C	TRP1099
C	LYS1254
C	MES1720

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1703

Chain	Residue
C	ARG1535
C	GLY1551
C	THR1552
C	LYS1553

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1704

Chain	Residue
C	LYS1553
C	HIS1622
C	SER1626

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1705

Chain	Residue
C	LYS1411
C	HIS1446
C	HIS1446

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1706

Chain	Residue
C	SER1259
C	ASN1262

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1707

Chain	Residue
C	PRO1424
C	GLU1425

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1708

Chain	Residue
C	PRO1301
C	ASP1302
C	VAL1345

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1709

Chain	Residue
C	ASN1214
C	TYR1215

site_id	EC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1710

Chain	Residue
C	MET1071
C	THR1074
C	SER1075
C	ASN1154
C	TYR1548
C	LYS1559
C	PRO1600
C	SER1602

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1711

Chain	Residue
C	GLN1081
C	THR1105
C	ARG1535

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1712

Chain	Residue
C	GLY1171
C	PRO1172
C	VAL1173
C	LYS1192
C	ILE1193
C	GLU1194

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1713

Chain	Residue
C	ASN1178
C	PHE1180
C	LYS1198

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1714

Chain	Residue
C	GLN1179
C	PHE1180
C	LYS1181
C	ARG1315
C	ALA1348

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1715

Chain	Residue
C	THR1399
C	HIS1423

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1716

Chain	Residue
C	CYS1490
C	LEU1491
C	ASP1492
C	TRP1495

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1717

Chain	Residue
C	ARG1620
C	MES1721

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1718

Chain	Residue
C	ARG1352
C	LYS1354

site_id	FC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES C 1719

Chain	Residue
C	ALA1369
C	ASN1371
C	GLU1378
C	SER1457
C	THR1458
C	GLY1459
C	ILE1460
C	TYR1461

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES C 1720

Chain	Residue
C	HIS1055
C	SER1056
C	THR1255
C	ARG1258
C	SO41702

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES C 1721

Chain	Residue
C	HIS1527
C	ASP1529
C	MET1613
C	ALA1615
C	THR1617
C	GLU1619
C	SO41717

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1722

Chain	Residue
C	CYS1610
C	CYS1612
C	CYS1635
C	CYS1653

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	987
Details	Domain: {"description":"Peptidase C9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00853","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	477
Details	Domain: {"description":"Macro","evidences":[{"source":"PROSITE-ProRule","id":"PRU00490","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	57
Details	Region: {"description":"Nucleolus localization signal","evidences":[{"source":"UniProtKB","id":"P08411","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"UniProtKB","id":"P27282","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"UniProtKB","id":"P08411","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Active site: {"description":"For cysteine protease nsP2 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00853","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8JUX6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23010928","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Site: {"description":"Cleavage; by protease nsP2","evidences":[{"source":"PubMed","id":"2141206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)