4GQS
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Summary for 4GQS
Entry DOI | 10.2210/pdb4gqs/pdb |
Related | 1OG2 1OG5 1PQ2 1R9O 2NNI 2NNJ |
Descriptor | Cytochrome P450 2C19, PROTOPORPHYRIN IX CONTAINING FE, (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone, ... (5 entities in total) |
Functional Keywords | monooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P33261 |
Total number of polymer chains | 4 |
Total formula weight | 222187.50 |
Authors | Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F. (deposition date: 2012-08-23, release date: 2012-11-14, Last modification date: 2023-09-13) |
Primary citation | Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F. Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19. J.Biol.Chem., 287:44581-44591, 2012 Cited by PubMed: 23118231DOI: 10.1074/jbc.M112.424895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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