4GQS

Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

4GQS の概要

• エントリーDOI: 10.2210/pdb4gqs/pdb
• 関連するPDBエントリー: 1OG2 1OG5 1PQ2 1R9O 2NNI 2NNJ
• 分子名称: Cytochrome P450 2C19, PROTOPORPHYRIN IX CONTAINING FE, (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone, ... (5 entities in total)
• 機能のキーワード: monooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P33261
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 222187.50

構造登録者

Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F. (登録日: 2012-08-23, 公開日: 2012-11-14, 最終更新日: 2023-09-13)

• 主引用文献: Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F.; Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.; J.Biol.Chem., 287:44581-44591, 2012; PubMed: 23118231; DOI: 10.1074/jbc.M112.424895

実験手法

X-RAY DIFFRACTION (2.87 Å)