4FR8

Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin

4FR8 の概要

• エントリーDOI: 10.2210/pdb4fr8/pdb
• 関連するPDBエントリー: 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9
• 分子名称: Aldehyde dehydrogenase, mitochondrial, propane-1,2,3-triyl trinitrate, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (9 entities in total)
• 機能のキーワード: rossmann fold, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix: P05091
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 441269.68

構造登録者

Lang, B.S.,Gruber, K. (登録日: 2012-06-26, 公開日: 2012-09-26, 最終更新日: 2024-02-28)

• 主引用文献: Lang, B.S.,Gorren, A.C.,Oberdorfer, G.,Wenzl, M.V.,Furdui, C.M.,Poole, L.B.,Mayer, B.,Gruber, K.; Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY.; J.Biol.Chem., 287:38124-38134, 2012; PubMed: 22988236; DOI: 10.1074/jbc.M112.371716

実験手法

X-RAY DIFFRACTION (2.2 Å)