4FR8
Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Aldehyde dehydrogenase, mitochondrial | polymer | 500 | 54466.5 | 8 | UniProt (P05091) Pfam (PF00171) In PDB | Homo sapiens (human) | ALDH class 2, ALDH-E2, ALDHI |
2 | A | propane-1,2,3-triyl trinitrate | non-polymer | 227.1 | 1 | Chemie (TNG) | |||
3 | F, A, C, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
4 | E, F, G, A, H... | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
5 | E, A, B, C, D | UREA | non-polymer | 60.1 | 6 | Chemie (URE) | |||
6 | E, F, G, A, H... | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
7 | E, G, H, B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
8 | G | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
9 | water | water | 18.0 | 2856 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 500 (UniProt: P05091)
PDB | External Database | Details |
---|---|---|
Gln 268 | Glu 285 | engineered mutation |
Ser 301 | Cys 318 | engineered mutation |
Ser 303 | Cys 320 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 435732.2 | |
Non-Polymers* | Number of molecules | 32 |
Total formula weight | 5537.5 | |
All* | Total formula weight | 441269.7 |