3SZ9
Crystal structure of human ALDH2 modified with the beta-elimination product of Aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
Summary for 3SZ9
| Entry DOI | 10.2210/pdb3sz9/pdb |
| Related | 3SZA 3SZB |
| Descriptor | Aldehyde dehydrogenase, mitochondrial, SODIUM ION, GUANIDINE, ... (6 entities in total) |
| Functional Keywords | aldh, aldi-3, inhibitor, rossmann fold, oxidoreductase, covalent adduct, mitochondria, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion matrix: P05091 |
| Total number of polymer chains | 8 |
| Total formula weight | 439845.46 |
| Authors | Perez-Miller, S.,Hurley, T.D. (deposition date: 2011-07-18, release date: 2011-11-02, Last modification date: 2023-09-13) |
| Primary citation | Khanna, M.,Chen, C.H.,Kimble-Hill, A.,Parajuli, B.,Perez-Miller, S.,Baskaran, S.,Kim, J.,Dria, K.,Vasiliou, V.,Mochly-Rosen, D.,Hurley, T.D. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J.Biol.Chem., 286:43486-43494, 2011 Cited by PubMed: 22021038DOI: 10.1074/jbc.M111.293597 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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