4FQF

Crystal structure of a thionitrate intermediate of human aldehyde dehydrogenase-2

Summary for 4FQF

Entry DOI	10.2210/pdb4fqf/pdb
Related	1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9
Descriptor	Aldehyde dehydrogenase, mitochondrial, NITROGEN DIOXIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (7 entities in total)
Functional Keywords	rossmann fold, oxidoreductase, aldehydes, esters, organic nitrates, nad, oxidoreductase-intermediate complex
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: P05091
Total number of polymer chains	4
Total formula weight	221385.75
Authors	Lang, B.S.,Gruber, K. (deposition date: 2012-06-25, release date: 2012-09-26, Last modification date: 2023-09-13)
Primary citation	Lang, B.S.,Gorren, A.C.,Oberdorfer, G.,Wenzl, M.V.,Furdui, C.M.,Poole, L.B.,Mayer, B.,Gruber, K. Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY. J.Biol.Chem., 287:38124-38134, 2012 Cited by PubMed: 22988236 DOI: 10.1074/jbc.M112.371716 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.281 Å)

Structure validation