4EJD
HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap
Summary for 4EJD
Entry DOI | 10.2210/pdb4ejd/pdb |
Related | 4EJ8 4EJK 4EJL |
Related PRD ID | PRD_000557 |
Descriptor | Protease, pepstatin, BETA-MERCAPTOETHANOL, ... (6 entities in total) |
Functional Keywords | apo protease, allostery, fragment binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499 |
Total number of polymer chains | 3 |
Total formula weight | 22837.21 |
Authors | Tiefenbrunn, T.,Stout, C.D. (deposition date: 2012-04-06, release date: 2013-05-01, Last modification date: 2014-02-19) |
Primary citation | Tiefenbrunn, T.,Forli, S.,Baksh, M.M.,Chang, M.W.,Happer, M.,Lin, Y.C.,Perryman, A.L.,Rhee, J.K.,Torbett, B.E.,Olson, A.J.,Elder, J.H.,Finn, M.G.,Stout, C.D. Small molecule regulation of protein conformation by binding in the Flap of HIV protease. Acs Chem.Biol., 8:1223-1231, 2013 Cited by PubMed: 23540839DOI: 10.1021/cb300611p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.103 Å) |
Structure validation
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