Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME A 101 |
| Chain | Residue |
| A | LEU10 |
| A | VAL11 |
| A | THR12 |
| A | CYS67 |
| A | HOH207 |
| B | LYS7 |
| B | HOH246 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1F1 A 102 |
| Chain | Residue |
| A | LYS55 |
| A | VAL56 |
| A | ARG57 |
| A | THR91 |
| A | GLN92 |
| A | GLY94 |
| A | HOH209 |
| A | HOH278 |
| B | HOH233 |
| A | PRO44 |
| A | LYS45 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 101 |
| Chain | Residue |
| A | GLY49 |
| A | GLY51 |
| A | GLY52 |
| B | PRO44 |
| B | MET46 |
| B | LYS55 |
| B | PRO81 |
| B | HOH225 |
| B | HOH251 |
| C | HOH104 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 102 |
| Chain | Residue |
| A | LYS7 |
| A | HOH227 |
| B | VAL11 |
| B | CYS67 |
| B | BME103 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 103 |
| Chain | Residue |
| A | LYS7 |
| A | HOH227 |
| B | THR12 |
| B | CYS67 |
| B | BME102 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN C OF PEPSTATIN |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | LYS45 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | ILE84 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | GLY48 |
| B | HOH231 |
| C | HOH102 |
| C | HOH103 |
| C | HOH105 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| A | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
