4EJD

HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap

Summary for 4EJD

• Entry DOI: 10.2210/pdb4ejd/pdb
• Related: 4EJ8 4EJK 4EJL
• Related PRD ID: PRD_000557
• Descriptor: Protease, pepstatin, BETA-MERCAPTOETHANOL, ... (6 entities in total)
• Functional Keywords: apo protease, allostery, fragment binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• Total number of polymer chains: 3
• Total formula weight: 22837.21

Authors

Tiefenbrunn, T.,Stout, C.D. (deposition date: 2012-04-06, release date: 2013-05-01, Last modification date: 2014-02-19)

• Primary citation: Tiefenbrunn, T.,Forli, S.,Baksh, M.M.,Chang, M.W.,Happer, M.,Lin, Y.C.,Perryman, A.L.,Rhee, J.K.,Torbett, B.E.,Olson, A.J.,Elder, J.H.,Finn, M.G.,Stout, C.D.; Small molecule regulation of protein conformation by binding in the Flap of HIV protease.; Acs Chem.Biol., 8:1223-1231, 2013; PubMed: 23540839; DOI: 10.1021/cb300611p

Experimental method

X-RAY DIFFRACTION (1.103 Å)