4EJD
HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10831.8 | 2 | UniProt (P12499) Pfam (PF00077) | Human immunodeficiency virus 1 | PR, Retropepsin |
| 2 | C (C) | pepstatin | polymer | 6 | 685.9 | 1 | BIRD (PRD_000557) | Streptomyces argenteolus subsp. toyonakensis | |
| 3 | D, G, H (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 3 | Chemie (BME) | |||
| 4 | E (A) | 1H-indole-6-carboxylic acid | non-polymer | 161.2 | 1 | Chemie (1F1) | |||
| 5 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | I, J, K (A, B, C) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P12499)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 496 | CONFLICT |
| Arg 41 | Lys 530 | CONFLICT |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22349.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 487.7 | |
| All* | Total formula weight | 22837.2 |
