4EBE
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
Summary for 4EBE
Entry DOI | 10.2210/pdb4ebe/pdb |
Related | 1T3N 2ALZ 3GV5 3GV7 3GV8 3H40 4EBC 4EBD |
Descriptor | DNA polymerase iota, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ... (7 entities in total) |
Functional Keywords | polymerase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q9UNA4 |
Total number of polymer chains | 3 |
Total formula weight | 52637.15 |
Authors | Eoff, R.L.,Ketkar, A.,Banerjee, S. (deposition date: 2012-03-23, release date: 2012-06-13, Last modification date: 2023-09-13) |
Primary citation | Ketkar, A.,Zafar, M.K.,Banerjee, S.,Marquez, V.E.,Egli, M.,Eoff, R.L. A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota. J.Am.Chem.Soc., 134:10698-10705, 2012 Cited by PubMed: 22632140DOI: 10.1021/ja304176q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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