4EBE

Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE DTP A 501

Chain	Residue
A	LEU35
A	LEU78
A	ASP126
A	LYS214
A	CA503
A	HOH609
A	HOH791
A	HOH807
A	HOH825
A	HOH843
A	HOH847
A	ASP36
A	HOH848
A	HOH849
P	DOC7
T	DT4
T	DG5
A	CYS37
A	PHE38
A	TYR39
A	THR65
A	TYR68
A	ARG71
A	LYS77

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP34
A	GLU127
A	HOH789
A	HOH825
A	HOH847
A	HOH849

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP34
A	LEU35
A	ASP126
A	DTP501
A	HOH825
A	HOH849

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	LYS237
A	ILE239
A	ILE242
A	HOH751
A	HOH808
A	HOH809
P	DC6
P	HOH113

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	ASP98
A	THR100
A	GLU304
A	HOH716
A	HOH794
A	HOH816
A	HOH846
A	HOH852
T	DG6

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL T 501

Chain	Residue
A	GLU305
A	ARG357
A	HOH814
T	DG5
T	DG6
T	HOH604
T	HOH620
T	HOH621

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216

Chain	Residue	Details
A	GLU127

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5

Chain	Residue	Details
A	ASP34
A	LEU35
A	ASP126

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N

Chain	Residue	Details
A	TYR39
A	ARG71

---