4EBE
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DTP A 501 |
| Chain | Residue |
| A | LEU35 |
| A | LEU78 |
| A | ASP126 |
| A | LYS214 |
| A | CA503 |
| A | HOH609 |
| A | HOH791 |
| A | HOH807 |
| A | HOH825 |
| A | HOH843 |
| A | HOH847 |
| A | ASP36 |
| A | HOH848 |
| A | HOH849 |
| P | DOC7 |
| T | DT4 |
| T | DG5 |
| A | CYS37 |
| A | PHE38 |
| A | TYR39 |
| A | THR65 |
| A | TYR68 |
| A | ARG71 |
| A | LYS77 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 502 |
| Chain | Residue |
| A | ASP34 |
| A | GLU127 |
| A | HOH789 |
| A | HOH825 |
| A | HOH847 |
| A | HOH849 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | ASP34 |
| A | LEU35 |
| A | ASP126 |
| A | DTP501 |
| A | HOH825 |
| A | HOH849 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA A 504 |
| Chain | Residue |
| A | LYS237 |
| A | ILE239 |
| A | ILE242 |
| A | HOH751 |
| A | HOH808 |
| A | HOH809 |
| P | DC6 |
| P | HOH113 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 505 |
| Chain | Residue |
| A | ASP98 |
| A | THR100 |
| A | GLU304 |
| A | HOH716 |
| A | HOH794 |
| A | HOH816 |
| A | HOH846 |
| A | HOH852 |
| T | DG6 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL T 501 |
| Chain | Residue |
| A | GLU305 |
| A | ARG357 |
| A | HOH814 |
| T | DG5 |
| T | DG6 |
| T | HOH604 |
| T | HOH620 |
| T | HOH621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 213 |
| Details | Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 65 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
