4E4D

Crystal structure of mouse RANKL-OPG complex

4E4D の概要

• エントリーDOI: 10.2210/pdb4e4d/pdb
• 関連するPDBエントリー: 1TNR 3ALQ 3K51 3ME2 3QBQ 3QO4
• 分子名称: Tumor necrosis factor ligand superfamily member 11, soluble form, Tumor necrosis factor receptor superfamily member 11B, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: tnf-related activation-induced cytokine-receptor, cysteine-rich domain, jelly-roll fold, cytokine-signaling protein complex, cytokine/signaling protein
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cytoplasm. Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted: O35235; Secreted: O08712
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37819.54

構造登録者

Nelson, C.A.,Fremont, D.H. (登録日: 2012-03-12, 公開日: 2012-10-24, 最終更新日: 2023-09-13)

• 主引用文献: Nelson, C.A.,Warren, J.T.,Wang, M.W.,Teitelbaum, S.L.,Fremont, D.H.; RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor.; Structure, 20:1971-1982, 2012; PubMed: 23039992; DOI: 10.1016/j.str.2012.08.030

実験手法

X-RAY DIFFRACTION (2.7 Å)