4BVV

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

4BVV の概要

• エントリーDOI: 10.2210/pdb4bvv/pdb
• 関連するPDBエントリー: 4BV5 4BV7 4BVC 4BVD 4BVW
• 分子名称: APOLIPOPROTEIN(A), 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, cardiovascular disease, drug discovery, optical biosensors
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9613.78

構造登録者

Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W. (登録日: 2013-06-28, 公開日: 2014-07-16, 最終更新日: 2023-12-20)

• 主引用文献: Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W.; Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A); To be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)