4AKN

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

Summary for 4AKN

Entry DOI	10.2210/pdb4akn/pdb
Related	1X0J 2YDW 2YEK 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4A9P 4ALG
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, ... (6 entities in total)
Functional Keywords	protein binding, inhibitor, histone, epigenetic reader
Biological source	HOMO SAPIENS
Total number of polymer chains	3
Total formula weight	54598.00
Authors	Chung, C.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O. (deposition date: 2012-02-26, release date: 2012-07-04, Last modification date: 2019-05-15)
Primary citation	Seal, J.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O.,Gellibert, F.,Nicodeme, E.,Krysa, G.,Kirilovsky, J.,Beinke, S.,Mccleary, S.,Rioja, I.,Bamborough, P.,Chung, C.,Gordon, L.,Lewis, T.,Walker, A.L.,Cutler, L.,Lugo, D.,Wilson, D.M.,Witherington, J.,Lee, K.,Prinjha, R.K. Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22:2968-, 2012 Cited by PubMed: 22437115 DOI: 10.1016/J.BMCL.2012.02.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation