4A9N

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopropyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide

Summary for 4A9N

Entry DOI	10.2210/pdb4a9n/pdb
Related	1X0J 2YDW 2YEK 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9O 4A9P
Descriptor	BROMODOMAIN CONTAINING 2, 1,2-ETHANEDIOL, N-CYCLOPROP-2-EN-1-YL-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-BENZENESULFONAMIDE, ... (6 entities in total)
Functional Keywords	signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	3
Total formula weight	55169.70
Authors	Chung, C.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-02-08, Last modification date: 2019-05-08)
Primary citation	Bamborough, P.,Diallo, H.,Goodacre, J.D.,Gordon, L.,Lewis, A.,Seal, J.T.,Wilson, D.M.,Woodrow, M.D.,Chung, C.W. Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55:587-, 2012 Cited by PubMed: 22136469 DOI: 10.1021/JM201283Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation