4A9N
N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopropyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | BROMODOMAIN CONTAINING 2 | polymer | 154 | 17908.7 | 3 | UniProt (P25440) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | HUMAN BRD2 |
| 2 | D, E, F, J, K... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 3 | G, L (A, B) | N-CYCLOPROP-2-EN-1-YL-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-BENZENESULFONAMIDE | non-polymer | 304.4 | 2 | Chemie (A9N) | |||
| 4 | H, I, M, P (A, B, C) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | N (C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | Q, R, S (A, B, C) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B, C: 67 - 200 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| Ser 49 | - | expression tag |
| His 50 | - | expression tag |
| His 51 | - | expression tag |
| His 52 | - | expression tag |
| His 53 | - | expression tag |
| His 54 | - | expression tag |
| His 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Ser 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Leu 59 | - | expression tag |
| Val 60 | - | expression tag |
| Pro 61 | - | expression tag |
| Arg 62 | - | expression tag |
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53726.2 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1443.5 | |
| All* | Total formula weight | 55169.7 |
