4A9N

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopropyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	BROMODOMAIN CONTAINING 2	polymer	154	17908.7	3	UniProt (P25440) Pfam (PF00439) In PDB	HOMO SAPIENS (HUMAN)	HUMAN BRD2
2	A, B, C	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
3	A, B	N-CYCLOPROP-2-EN-1-YL-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-BENZENESULFONAMIDE	non-polymer		304.4	2	Chemie (A9N)
4	A, B, C	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	C	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
6		water	water		18.0	281	Chemie (HOH)

Sequence modifications

A, B, C: 67 - 200 (UniProt: P25440)

PDB	External Database	Details
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53726.2
Non-Polymers*	Number of molecules	13
	Total formula weight	1443.5
All*	Total formula weight	55169.7

*Water molecules are not included.