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4ALG

N-Terminal Bromodomain of Human BRD2 With IBET-151

Summary for 4ALG
Entry DOI10.2210/pdb4alg/pdb
Related1X0J 2YDW 2YEK 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALH
DescriptorBROMODOMAIN-CONTAINING PROTEIN 2, ACETATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywordssignaling protein, inhibitor, histone, epigenetic reader
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight18475.31
Authors
Chung, C.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O. (deposition date: 2012-03-03, release date: 2012-07-04, Last modification date: 2019-05-15)
Primary citationSeal, J.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O.,Gellibert, F.,Nicodeme, E.,Krysa, G.,Kirilovsky, J.,Beinke, S.,Mccleary, S.,Rioja, I.,Bamborough, P.,Chung, C.,Gordon, L.,Lewis, T.,Walker, A.L.,Cutler, L.,Lugo, D.,Wilson, D.M.,Witherington, J.,Lee, K.,Prinjha, R.K.
Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).
Bioorg.Med.Chem.Lett., 22:2968-, 2012
Cited by
PubMed: 22437115
DOI: 10.1016/J.BMCL.2012.02.041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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