4ALG

N-Terminal Bromodomain of Human BRD2 With IBET-151

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	154	17908.7	1	UniProt (P25440) Pfam (PF00439)	HOMO SAPIENS (HUMAN)	BRD2, O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN
2	B (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (A)	7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE	non-polymer		415.4	1	Chemie (1GH)
5	E (A)	water	water		18.0	127	Chemie (HOH)

Sequence modifications

A: 21 - 154 (UniProt: P25440)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Ser 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Ser 10	-	expression tag
Ser 11	-	expression tag
Gly 12	-	expression tag
Leu 13	-	expression tag
Val 14	-	expression tag
Pro 15	-	expression tag
Arg 16	-	expression tag
Gly 17	-	expression tag
Ser 18	-	expression tag
His 19	-	expression tag
Met 20	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	17908.7
Non-Polymers*	Number of molecules	3
	Total formula weight	566.6
All*	Total formula weight	18475.3

*Water molecules are not included.