4ALG
N-Terminal Bromodomain of Human BRD2 With IBET-151
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1144 |
| Chain | Residue |
| A | ARG54 |
| A | LYS69 |
| A | HOH2024 |
| A | HOH2053 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1145 |
| Chain | Residue |
| A | HOH2102 |
| A | HOH2125 |
| A | HOH2126 |
| A | ASP58 |
| A | HIS68 |
| A | ASP114 |
| A | ASP115 |
| A | HOH2042 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1GH A 1146 |
| Chain | Residue |
| A | TRP51 |
| A | PRO52 |
| A | PHE53 |
| A | LEU62 |
| A | LEU64 |
| A | HIS68 |
| A | LYS72 |
| A | ASN110 |
| A | ILE116 |
| A | HOH2034 |
| A | HOH2055 |
| A | HOH2126 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA50-TYR109 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
