4AKN

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	153	17779.5	3	UniProt (P25440) Pfam (PF00439) In PDB	HOMO SAPIENS	O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN HUMAN BRD2
2	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
3	A, B	4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid	non-polymer		415.5	2	Chemie (S5B)
4	A, C	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	C	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
6		water	water		18.0	333	Chemie (HOH)

Sequence modifications

A, B, C: 67 - 199 (UniProt: P25440)

PDB	External Database	Details
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag
-	Lys 193	deletion

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53338.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1259.4
All*	Total formula weight	54598.0

*Water molecules are not included.