4AKN
N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | BROMODOMAIN-CONTAINING PROTEIN 2 | polymer | 153 | 17779.5 | 3 | UniProt (P25440) Pfam (PF00439) | HOMO SAPIENS | O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN HUMAN BRD2 |
| 2 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | E, H (A, B) | 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid | non-polymer | 415.5 | 2 | Chemie (S5B) | |||
| 4 | F, G, J (A, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | I (C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | K, L, M (A, B, C) | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence modifications
A, B, C: 67 - 199 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| Ser 49 | - | expression tag |
| His 50 | - | expression tag |
| His 51 | - | expression tag |
| His 52 | - | expression tag |
| His 53 | - | expression tag |
| His 54 | - | expression tag |
| His 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Ser 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Leu 59 | - | expression tag |
| Val 60 | - | expression tag |
| Pro 61 | - | expression tag |
| Arg 62 | - | expression tag |
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
| - | Lys 193 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53338.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1259.4 | |
| All* | Total formula weight | 54598.0 |
