4AKN
N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1187 |
| Chain | Residue |
| A | ASN146 |
| A | THR150 |
| A | TYR153 |
| A | GLU170 |
| A | HOH2140 |
| B | ASN146 |
| B | THR150 |
| B | TYR153 |
| B | GLU170 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE S5B A 1188 |
| Chain | Residue |
| A | TRP97 |
| A | PRO98 |
| A | PHE99 |
| A | LEU108 |
| A | LEU110 |
| A | ASN156 |
| A | HOH2029 |
| A | HOH2034 |
| A | HOH2063 |
| B | GLN94 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1189 |
| Chain | Residue |
| A | ARG100 |
| A | HOH2020 |
| A | HOH2022 |
| A | HOH2141 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1190 |
| Chain | Residue |
| A | THR125 |
| A | ARG128 |
| A | ARG129 |
| A | HOH2144 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE S5B B 1184 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PHE99 |
| B | LYS107 |
| B | LEU108 |
| B | ASN156 |
| B | HOH2022 |
| B | HOH2040 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 1183 |
| Chain | Residue |
| C | VAL103 |
| C | ASN156 |
| C | ILE162 |
| C | HOH2024 |
| C | HOH2067 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1184 |
| Chain | Residue |
| B | ARG100 |
| B | HOH2014 |
| B | HOH2015 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH2047 |
| C | HOH2079 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
