4AKN

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 1187

Chain	Residue
A	ASN146
A	THR150
A	TYR153
A	GLU170
A	HOH2140
B	ASN146
B	THR150
B	TYR153
B	GLU170

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE S5B A 1188

Chain	Residue
A	TRP97
A	PRO98
A	PHE99
A	LEU108
A	LEU110
A	ASN156
A	HOH2029
A	HOH2034
A	HOH2063
B	GLN94

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1189

Chain	Residue
A	ARG100
A	HOH2020
A	HOH2022
A	HOH2141

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1190

Chain	Residue
A	THR125
A	ARG128
A	ARG129
A	HOH2144

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE S5B B 1184

Chain	Residue
A	GLN94
B	TRP97
B	PHE99
B	LYS107
B	LEU108
B	ASN156
B	HOH2022
B	HOH2040

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 1183

Chain	Residue
C	VAL103
C	ASN156
C	ILE162
C	HOH2024
C	HOH2067

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site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1184

Chain	Residue
B	ARG100
B	HOH2014
B	HOH2015
C	ARG128
C	ASN132
C	TYR134
C	HOH2047
C	HOH2079

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
C	TYR155
C	ASN156
C	LYS157
A	TYR155
A	ASN156
A	LYS157
B	ASP112
B	TYR155
B	ASN156
B	LYS157
C	ASP112

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161
B	ASP160
B	ASP161
C	ASP160
C	ASP161

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