4A9O
N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 5 ethyl-3-methyl-4-phenyl-1, 2-oxazole
Summary for 4A9O
Entry DOI | 10.2210/pdb4a9o/pdb |
Related | 1X0J 2YDW 2YEK 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M |
Descriptor | BROMODOMAIN CONTAINING 2, 1,2-ETHANEDIOL, 5-ETHYL-3-METHYL-4-PHENYL-1,2-OXAZOLE, ... (5 entities in total) |
Functional Keywords | signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus (By similarity): P25440 |
Total number of polymer chains | 3 |
Total formula weight | 54700.22 |
Authors | |
Primary citation | Bamborough, P.,Diallo, H.,Goodacre, J.D.,Gordon, L.,Lewis, A.,Seal, J.T.,Wilson, D.M.,Woodrow, M.D.,Chung, C.W. Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55:587-, 2012 Cited by PubMed: 22136469DOI: 10.1021/JM201283Q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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