4A9O
N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 5 ethyl-3-methyl-4-phenyl-1, 2-oxazole
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1189 |
| Chain | Residue |
| A | GLN94 |
| A | HOH2032 |
| A | HOH2176 |
| A | HOH2177 |
| B | TRP97 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE A9O A 1190 |
| Chain | Residue |
| A | ASN156 |
| A | HOH2082 |
| B | EDO1184 |
| A | PRO98 |
| A | PHE99 |
| A | LEU110 |
| A | TYR155 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1191 |
| Chain | Residue |
| A | ARG100 |
| A | HOH2024 |
| A | HOH2027 |
| A | HOH2029 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1192 |
| Chain | Residue |
| A | ARG128 |
| A | ARG129 |
| A | HOH2115 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1184 |
| Chain | Residue |
| A | TRP97 |
| A | A9O1190 |
| B | GLN94 |
| B | HOH2019 |
| B | HOH2129 |
| B | HOH2130 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE A9O B 1185 |
| Chain | Residue |
| B | PRO98 |
| B | PHE99 |
| B | LEU110 |
| B | TYR155 |
| B | ASN156 |
| B | HOH2045 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE A9O C 1183 |
| Chain | Residue |
| C | PRO98 |
| C | LEU110 |
| C | TYR155 |
| C | ASN156 |
| C | HOH2036 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1184 |
| Chain | Residue |
| B | ARG100 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH2060 |
| C | HOH2099 |
| C | HOH2100 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
