2YDW

Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GW841819X

Summary for 2YDW

• Entry DOI: 10.2210/pdb2ydw/pdb
• Related: 1X0J
• Descriptor: BROMODOMAIN-CONTAINING PROTEIN 2, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: nuclear protein, histone, epigenetic reader
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus (Probable): P25440
• Total number of polymer chains: 3
• Total formula weight: 54705.10

Authors

Chung, C.,Delves, C.,Woodward, R.,Mirguet, O.,Nicodeme, E. (deposition date: 2011-03-24, release date: 2011-06-15, Last modification date: 2023-12-20)

• Primary citation: Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E.; Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.; J.Med.Chem., 54:3827-, 2011; PubMed: 21568322; DOI: 10.1021/JM200108T

Experimental method

X-RAY DIFFRACTION (1.9 Å)