2YDW
Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GW841819X
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE WSH A 1183 |
| Chain | Residue |
| A | TRP97 |
| A | HOH2096 |
| A | HOH2123 |
| C | GLN94 |
| A | PRO98 |
| A | VAL103 |
| A | LEU110 |
| A | TYR155 |
| A | ASN156 |
| A | ILE162 |
| A | HOH2043 |
| A | HOH2095 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE WSH B 1182 |
| Chain | Residue |
| B | TRP97 |
| B | PRO98 |
| B | VAL103 |
| B | LEU110 |
| B | TYR155 |
| B | ASN156 |
| B | ILE162 |
| B | HOH2026 |
| B | HOH2062 |
| B | HOH2066 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE WSH C 1183 |
| Chain | Residue |
| C | PRO98 |
| C | LEU110 |
| C | TYR155 |
| C | ASN156 |
| C | LYS157 |
| C | ASP160 |
| C | ILE162 |
| C | HOH2037 |
| C | HOH2103 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1183 |
| Chain | Residue |
| B | ARG128 |
| B | ASN132 |
| B | TYR134 |
| B | HOH2043 |
| B | HOH2079 |
| B | HOH2080 |
| C | ARG100 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
