4AKN

N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid

4AKN の概要

• エントリーDOI: 10.2210/pdb4akn/pdb
• 関連するPDBエントリー: 1X0J 2YDW 2YEK 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4A9P 4ALG
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: protein binding, inhibitor, histone, epigenetic reader
• 由来する生物種: HOMO SAPIENS
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54598.00

構造登録者

Chung, C.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O. (登録日: 2012-02-26, 公開日: 2012-07-04, 最終更新日: 2024-05-08)

• 主引用文献: Seal, J.,Lamotte, Y.,Donche, F.,Bouillot, A.,Mirguet, O.,Gellibert, F.,Nicodeme, E.,Krysa, G.,Kirilovsky, J.,Beinke, S.,Mccleary, S.,Rioja, I.,Bamborough, P.,Chung, C.,Gordon, L.,Lewis, T.,Walker, A.L.,Cutler, L.,Lugo, D.,Wilson, D.M.,Witherington, J.,Lee, K.,Prinjha, R.K.; Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).; Bioorg.Med.Chem.Lett., 22:2968-, 2012; PubMed: 22437115; DOI: 10.1016/J.BMCL.2012.02.041

実験手法

X-RAY DIFFRACTION (1.82 Å)